Yak Cardiac Molecular Atlas Under Nutritional Supplementation, 12 Animals

Yiqun Chen's dataset from 2026 provides an integrative transcriptomic-proteomic atlas of yak cardiac tissue. It contains data from 12 male Muli yaks subjected to grazing or winter supplementary feeding over a 60-day period, yielding 140 differentially expressed genes and 254 differentially expressed proteins. The data was last updated on 2026-04-14.

Use Cases

• Identify biomarkers for nutritional status based on selenoprotein expression levels like GPX1 and SELENOW.
• Study post-transcriptional regulation in cardiac tissue based on the decoupling between mRNA and protein levels.
• Analyze immune response attenuation in myocardial tissue based on stress-responsive effectors like ULBP13 and GZMB.
• Model the impact of nutritional supplementation on redox fortification pathways in high-altitude ruminants.

Strengths

• Integrates two molecular data layers: 140 differentially expressed genes and 254 differentially expressed proteins.
• Includes 9-quadrant integration analysis across 4,080 cognate gene-protein pairs.
• Features specific, high-discriminatory biomarkers (GPX1 and SELENOW with AUC=1.00).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single, small-scale study with 12 animals, limiting generalizability.
• The dataset is very small (10.9 KB), suggesting it contains summary or processed results rather than raw sequencing data.

Provenance

Source

Yiqun Chen via figshare.

Collection Method

Data from a completely randomized 60-day intervention with myocardial specimens interrogated via RNA sequencing and data-independent acquisition mass spectrometry.

Time Range

Intervention period of 60 days.

Freshness

Last updated 2026-04-14 12:38:56; freshness should be verified.

Geography

Qinghai-Tibet Plateau.