Table 1_Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glom

Yiming Jin's 2026 case report details a 55-year-old male with ANCA-associated glomerulonephritis who developed acute severe thrombocytopenia and leukopenia after a second dose of obinutuzumab. The document includes a literature review of this rare adverse effect, which is primarily reported in hematologic malignancies. The dataset is a 3.2 MB DOCX file shared under a CC-BY-4.0 license.

Use Cases

• Analyze the timeline and severity of cytopenias based on the reported platelet and white blood cell count nadirs.
• Review literature on obinutuzumab-induced acute thrombocytopenia (OIAT) in autoimmune versus hematologic disease settings.
• Study potential early warning signs for hematologic toxicity based on the described rapid platelet decline.

Strengths

• Includes specific clinical measurements, such as platelet count dropping from 121 × 10⁹/L to 2.5 × 10⁹/L.
• Presents a detailed timeline of patient recovery, with white blood cell recovery within one week and platelet recovery taking 45 days.
• Document is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is a single case report and literature review, which limits generalizability.
• Last updated 2026-05-05 05:24:45; freshness should be verified.

Provenance

Source

Yiming Jin via figshare

Collection Method

Clinical case documentation and literature review.

Freshness

Last updated 2026-05-05 05:24:45.