Table 1_Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glom

A 55-year-old male with ANCA-associated glomerulonephritis developed acute severe thrombocytopenia and leukopenia after a second dose of obinutuzumab. This case report, authored by Yiming Jin and published on figshare in May 2026, documents a platelet count drop from 121 × 10⁹/L to 2.5 × 10⁹/L and a white blood cell count nadir of 0.6 × 10⁹/L. It is described as the first reported case of obinutuzumab-induced acute bicytopenia in an autoimmune disease setting.

Use Cases

• Analyzing rare adverse drug reaction timelines based on documented platelet and white blood cell count trajectories.
• Reviewing literature on obinutuzumab safety profiles in autoimmune versus hematologic malignancy contexts.
• Identifying potential early warning signs for hematologic toxicity based on the described rapid decline in platelet count.

Strengths

• Provides detailed clinical timeline with specific lab values (e.g., platelet count drop to 2.5 × 10⁹/L).
• Identifies a novel case as the first reported instance of this specific adverse event in an autoimmune disease context.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 3.2 MB file size suggests the primary content is a document, not a structured data table.

Provenance

Source

figshare

Collection Method

Clinical case report and literature review.

Freshness

Last updated 2026-05-05 05:24:45; freshness should be verified.