Parkinson's Disease and Sleep Apnea: Cytokine Profiles and Clinical Scores for 48 Patients

A cross-sectional study of 48 patients with Parkinson's disease, conducted by Carlos Mauricio Oliveira de Almeida and last updated in May 2026. The data includes polysomnography results, clinical evaluations, and multiplex cytokine profiling, investigating links between obstructive sleep apnea severity and inflammatory markers. Obstructive sleep apnea was diagnosed in 54.2% of the patient cohort.

Use Cases

• Modeling associations between sleep apnea severity and motor scores (UPDRS-II/III) based on clinical evaluation data.
• Identifying inflammatory signatures (e.g., Th1/Th2 cytokine axes) linked to moderate-to-severe OSA based on multiplex cytokine profiling.
• Analyzing network connectivity of cytokines (e.g., IL-6, TNF-α, CCL2) to study systemic immune reorganization driven by intermittent hypoxia.
• Investigating correlations between sleep parameters (REM sleep, arousal index, oxygen desaturation) and patient quality of life metrics.

Strengths

• Includes multiplex cytokine profiling for a panel of specific markers (e.g., IL-6, TNF-α, IFN-γ, IL-13, CCL2, CXCL1, IL-4, IL-1β, IL-18, CXCL10, GM-CSF).
• Combines polysomnography-derived sleep parameters with clinical evaluation scores (UPDRS-II/III) and quality of life assessments.
• Dataset is openly available under a CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for certain statistical or machine learning tasks.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.5 KB), indicating a limited sample size of 48 patients.

Provenance

Source

Carlos Mauricio Oliveira de Almeida via figshare

Collection Method

Clinical evaluation, polysomnography (PSG), and multiplex cytokine profiling of 48 patients in a cross-sectional study.

Freshness

Last updated 2026-05-18 05:39:38; freshness should be verified.