Oral Microbiome Profiles by Periodontitis Stage in a Korean Population

A 2026 pilot study by Mu-Yeol Cho profiles the oral microbiome across periodontal disease stages in 74 Korean adults. The dataset includes 16S rRNA gene sequencing results from mouthwash samples for healthy controls and Stage I–II and Stage III–IV periodontitis groups. Analyses cover alpha diversity, beta diversity, differential abundance of genera, and core microbiome identification.

Use Cases

• Train classification models to predict periodontitis stage based on microbiome diversity metrics mentioned in the description
• Identify potential microbial biomarkers for periodontal health based on differential abundance analysis results
• Study polymicrobial synergy in disease pathogenesis using the core microbiome and pathogen prevalence data
• Benchmark oral microbiome profiles in Korean populations against other demographic groups

Strengths

• Includes data from 74 participants across three clinically defined groups (24 healthy, 12 Stage I-II, 38 Stage III-IV)
• Analysis identified 14 genera significantly associated with disease status and a core microbiome of 40 universally present genera
• Sequencing targeted the V3–V4 hypervariable region of the 16S rRNA gene, a standard for microbial profiling

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset is small (31.5 KB), indicating limited scope and sample size

Provenance

Source

figshare, author Mu-Yeol Cho

Collection Method

Pilot prospective cross-sectional study using 16S rRNA gene sequencing of mouthwash samples

Freshness

Last updated 2026-04-27 05:16:24; freshness should be verified

Geography

Korean population