TgF344-AD Rat Model: Oropharyngeal Dysphagia and Amyloid Beta Pathology

15 male TgF344-AD and Wildtype Fisher 344 rats underwent deglutition assessments and PET imaging at 11 months of age. The dataset, authored by M. J. Cullins and last updated in April 2026, contains results correlating amyloid beta pathology in specific brain regions with swallowing function deficits.

Use Cases

• Correlating amyloid beta levels in brain regions like the nucleus ambiguus with swallowing onset delays.
• Analyzing changes in aerodigestive coordination, such as apnea duration and post-swallow inhale patterns.
• Investigating altered oral processing metrics like bolus size and mastication rate in an AD model.
• Studying the relationship between PET imaging data from specific ROIs and functional swallowing assessments.

Strengths

• Data from a controlled animal model study with 15 subjects.
• Correlates specific amyloid beta pathology in brainstem nuclei with functional swallowing deficits.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Dataset is very small at 20.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

M. J. Cullins via figshare.

Collection Method

Videofluoroscopic swallow study, pasta biting task, and PET imaging using [¹¹C]PiB radiotracer.

Time Range

Data collected at the 11-month age point for the rats.

Freshness

Last updated 2026-04-13 05:30:28.

Geography

Laboratory study; geographic coverage is not specified.