Homocysteine-Androgen Correlations in PCOS by Reproductive Outcome

875 PCOS patients were analyzed in a retrospective study by Qian Han, investigating outcome-specific associations between homocysteine and androgen profiles. The cohort was classified into infertility (302 patients) and pregnancy (573 patients) groups, with the pregnancy group further subdivided into live birth (266) and spontaneous abortion (292) cases. This research, last updated in April 2026, found that metabolic disturbances and HCY-androgen correlations varied significantly across these reproductive outcomes.

Use Cases

• Analyze correlations between homocysteine (HCY) and specific androgens like total testosterone (TT) or dehydroepiandrosterone (DHEA) across patient subgroups.
• Build classification models to predict reproductive outcomes (infertility, live birth, spontaneous abortion) using patient metabolic and hormonal profiles.
• Investigate the divergent association patterns where HCY is positively linked to TT in the live birth group but negatively linked to DHEA in the spontaneous abortion group.
• Validate findings on the independent associations of HCY with total testosterone, bioavailable testosterone, free testosterone, and free androgen index in infertile patients.

Strengths

• Contains data from 875 clinically diagnosed PCOS patients, providing a substantial sample for analysis.
• Clear subgroup stratification with 302 infertility, 266 live birth, and 292 spontaneous abortion cases enables outcome-specific comparisons.
• Analysis includes specific hormonal metrics (e.g., TT, Bio-T, FT, FAI, DHEA) and their statistical associations (β coefficients, P-values) with homocysteine.

Limitations

• The dataset is very small at 53.0 KB, suggesting it contains summary statistics or a limited subset of the raw clinical data.
• As a retrospective study, it may be subject to biases inherent in observational data collection.
• Specific patient-level data columns, raw measurements, and demographic details are not provided in the description.

Provenance

Source

Figshare, authored by Qian Han.

Collection Method

Retrospective clinical study of enrolled PCOS patients, using Spearman correlation and multivariable linear regression.

Freshness

Last updated in April 2026, indicating the data is current.