Oxidative Stress and Antioxidant Markers in Oral Leukoplakia: A Meta-Analysis

A meta-analysis of 12 case-control studies from database inception to May 1, 2025, comparing oxidative stress markers in patients with oral leukoplakia versus healthy controls. The dataset, authored by Xueru Chen and last updated in April 2026, contains pooled results for five pro-oxidant and antioxidant markers, including malondialdehyde, glutathione, superoxide dismutase, glutathione peroxidase, and catalase.

Use Cases

• Identify potential diagnostic biomarkers for oral leukoplakia based on pooled oxidative stress marker levels.
• Compare the redox balance status between patient and control groups using the reported mean differences and confidence intervals.
• Support systematic review findings on the link between oxidative stress and oral leukoplakia pathogenesis.

Strengths

• Includes results from 12 selected studies, providing a synthesized evidence base.
• Reports specific quantitative findings for five key biomarkers, including mean differences and 95% confidence intervals.
• Has a registered systematic review protocol (CRD42025642682), indicating a structured methodology.

Limitations

• The dataset is very small at 14.4 KB, suggesting it contains summary results rather than raw study data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of literature from PubMed, Embase, Web of Science, and the Cochrane Library.

Time Range

Studies from database inception to May 1, 2025.

Freshness

Last updated 2026-04-21 04:22:06; freshness should be verified.