Urinary Metabolomics Data for Methyl Acetate Poisoning in Rats and Humans

Metabolite data from a cross-species study investigating methyl acetate poisoning. The dataset includes results from subacute poisoning rat models and an occupational human cohort, analyzed via UPLC-QTOF/MS. It was authored by Jiayi Lv and last updated on 2026-04-17.

Use Cases

• Identify potential biomarkers for methyl acetate poisoning based on significantly altered metabolites.
• Investigate toxicological mechanisms involving oxidative stress pathways like the TCA cycle and glutathione metabolism.
• Differentiate between methyl acetate and methanol exposure using candidate biomarkers like 20-COOH-LTB4 and SAH.
• Validate cross-species conservation of toxic responses by comparing rat model and human cohort data.

Strengths

• Identifies 41 significantly altered metabolites in rat models and 16 in human subjects.
• Highlights two candidate biomarkers (20-COOH-LTB4 and SAH) showing cross-species conservation.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (1.2 MB), suggesting a limited number of observations or features.

Provenance

Source

figshare, author Jiayi Lv.

Collection Method

Untargeted metabolomic analysis of urine samples from rat models and human subjects using UPLC-QTOF/MS.

Freshness

Last updated 2026-04-17 04:11:57; freshness should be verified.