Vaginal and Oral Microbiome Changes After Parabolic Flight in Women

Begum Aydogan Mathyk's dataset contains metagenomic sequencing data from vaginal and oral microbiomes of reproductive-age women before and after parabolic flight. The data includes taxonomic composition, metabolic pathway analysis, and integrated stress response parameters like cortisol and short-chain fatty acids. It was last updated on 2026-05-25 and is shared under a CC-BY-4.0 license.

Use Cases

• Compare taxonomic diversity changes between body sites based on pre- and post-flight alpha and beta diversity analysis.
• Identify key microbial species associated with physiological stress based on Random Forest model results highlighting Lactobacillus crispatus.
• Analyze shifts in microbial metabolic functions based on pathway enrichment data for fatty acid biosynthesis and nucleotide metabolism.
• Investigate correlations between host stress markers and microbiome composition based on integrated cortisol and cytokine data.

Strengths

• Dataset integrates multiple data types: metagenomic sequencing, taxonomic profiles, metabolic pathways, and host physiological parameters.
• Results include specific, quantified findings, such as 57.9% of vaginal species showing significant postflight changes compared to 2.54% of oral species.
• Analysis employs established bioinformatics tools like MetaPhlAn and HUMAnN, suggesting a structured methodological approach.

Limitations

• The dataset is very small at 15.5 KB, indicating limited scope, likely a summary document rather than raw sequencing data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Sample size, participant demographics, and specific temporal coverage are not detailed in the provided metadata.

Provenance

Source

Begum Aydogan Mathyk

Collection Method

Metagenomic shotgun sequencing of pre- and post-parabolic flight samples, analyzed with KneadData, MetaPhlAn, and HUMAnN.

Freshness

Last updated 2026-05-25 06:05:33; freshness should be verified.