PBMC Secretion of FGF, PDGF, VEGF, and GM-CSF in Endometriosis

36 women with endometriosis and 44 controls provided peripheral blood mononuclear cells (PBMCs) for an in vitro case–control study. Marcin Sadlocha authored this dataset, which quantifies secretion levels of fibroblast growth factor, platelet-derived growth factor, vascular endothelial growth factor, and granulocyte–macrophage colony-stimulating factor under basal and stimulated conditions. The data was last updated on June 4, 2026.

Use Cases

• Compare cytokine secretion profiles between patient groups based on the measured FGF, PDGF, VEGF, and GM-CSF concentrations.
• Investigate the effect of mitogenic stimulation on immune cell secretory capacity based on the phytohemagglutinin (PHA) activation condition.
• Perform logistic regression analysis to explore biomarkers for endometriosis based on the baseline growth factor measures.
• Apply false discovery rate adjustment methods for multiple testing on multiplex immunoassay data.

Strengths

• The study design includes a control group of 44 individuals for comparison with 36 cases.
• Secretion was measured under two standardized conditions: basal and after PHA stimulation.
• Data analysis employed nonparametric tests and false discovery rate adjustment for multiple comparisons.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 27.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

PBMCs were isolated from peripheral blood, cultured for 24 hours, and supernatant concentrations were quantified using a multiplex bead-based immunoassay (Bio-Plex/Luminex).

Freshness

Last updated 2026-06-04 05:39:59; freshness should be verified.