PD-1/PD-L1 Inhibitors Plus Chemotherapy for Endometrial Cancer: A Meta-Analysis of 10 RCTs

A systematic review and meta-analysis of 10 randomized controlled trials involving 4,052 patients with advanced or metastatic endometrial cancer. The dataset, authored by Zhilong Huang and last updated in June 2026, pools outcomes including progression-free survival, overall survival, and treatment-related adverse events to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors combined with first-line chemotherapy.

Use Cases

• Compare overall survival outcomes between combination therapy and chemotherapy alone based on the reported median values.
• Analyze the relative risk of different response types (complete, partial, stable, progressive disease) from the pooled meta-analysis results.
• Assess the safety profile of the treatment combination based on the reported common adverse events.
• Investigate differential treatment benefits between dMMR and pMMR patient subgroups as indicated in the conclusion.

Strengths

• Includes data from 10 randomized controlled trials, a standard for high-quality clinical evidence.
• Aggregates results from 4,052 individual patient records, providing substantial statistical power.
• Reports specific quantitative outcomes, such as median overall survival (43.7 vs. 29.1 months) and relative risks with confidence intervals.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analytical methods.
• The primary data file is a DOCX document (1.3 MB), which may require parsing to extract structured data.

Provenance

Source

Systematic literature search of PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov.

Collection Method

Meta-analysis performed on pooled outcomes from identified randomized controlled trials.

Time Range

Literature search covered from database inception to November 26, 2025.

Freshness

Last updated 2026-06-01 05:23:04; freshness should be verified.