Quinolone-Associated Pemphigoid Reports from FDA Adverse Event System

183 reports of pemphigoid linked to quinolone antibiotics were identified in the FDA Adverse Event Reporting System (FAERS). The analysis, authored by Xin Li and updated in April 2026, used disproportionality methods to detect significant signals for ofloxacin, ciprofloxacin, and levofloxacin. Most events occurred within 30 days of drug initiation, indicating a short latency pattern.

Use Cases

• Signal detection for drug safety based on disproportionality analysis results mentioned in the description
• Analyzing demographic susceptibility patterns based on subgroup analyses by age and sex
• Investigating latency periods for adverse events based on the reported short onset pattern
• Corroborating findings with published literature based on the described interaction analysis

Strengths

• Includes 183 specific case reports of quinolone-associated pemphigoid
• Provides disproportionality signals (ROR) for specific antibiotics like ofloxacin (ROR=2.75)
• Integrates findings with published literature for corroboration
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect reporting bias inherent to the FAERS spontaneous reporting system

Provenance

Source

FDA Adverse Event Reporting System (FAERS)

Collection Method

Analysis of spontaneous reports using disproportionality methods (ROR, PRR, BCPNN) and literature review

Time Range

Time range of FAERS data analyzed is not specified

Freshness

Last updated 2026-04-15 05:22:40; freshness should be verified

Geography

Geographic coverage is not specified, but FAERS is a U.S. system