Meta-Analysis of Perioperative Esketamine for Postoperative Sleep Disturbance Prevention

A systematic review and meta-analysis of 22 randomized controlled trials published up to March 10, 2026, assessing the efficacy and safety of perioperative esketamine for preventing postoperative sleep disturbance in adults. The analysis was conducted by Jinfang Zeng and includes pooled risk ratios for sleep outcomes on postoperative days 1-7. The dataset is a 12.0 KB document summarizing the review's methods, results, and conclusions.

Use Cases

• Meta-analysis of drug efficacy based on pooled risk ratios from 22 randomized controlled trials.
• Assessing clinical heterogeneity in surgical outcomes based on differences in patient populations and esketamine regimens described.
• Evaluating the certainty of evidence for medical interventions using GRADE and trial sequential analysis methods mentioned.

Strengths

• Includes 22 randomized controlled trials, a specific number of data sources.
• Reports specific pooled risk ratios with confidence intervals for outcomes on postoperative days 1, 2, 3, and 7.
• Employs multiple robustness checks including sensitivity analysis and trial sequential analysis as described.

Limitations

• The primary data is a summary document (12.0 KB); the underlying trial-level data is not provided.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the review text.
• Clinical heterogeneity is noted due to differences in surgical populations and assessment methods, which may limit generalizability.

Provenance

Source

figshare, author Jinfang Zeng.

Collection Method

Systematic review and meta-analysis of literature from PubMed, Embase, Cochrane Library, and CNKI.

Time Range

Literature searched from database inception to March 10, 2026.

Freshness

Last updated 2026-06-03 06:08:22.