Perioperative Hypersensitivity Reactions in a Lebanese Clinic 2018-2023

A 5-year retrospective study from a Lebanese tertiary allergy clinic includes 255 patients evaluated for perioperative hypersensitivity reactions. Skin prick test results for opioids, neuromuscular blocking agents, hypnotics, local anesthetics, latex, and patent blue identified causative agents, with 97.3% of patients showing a positive reaction to at least one substance. The study was authored by Diane Antonios and provides insights into reaction characteristics and sensitization patterns in Lebanon.

Use Cases

• Analyze sensitization frequencies to specific agents like morphine, rocuronium, and latex across 255 patient records.
• Investigate co-sensitization patterns within drug classes, such as between rocuronium and cisatracurium or morphine and pethidine.
• Identify causative agents from skin prick test results for the subset of 124 patients with a history of perioperative hypersensitivity reactions.
• Compare symptom profiles ranging from mucocutaneous manifestations to cardiopulmonary arrest among referred patients.

Strengths

• Data covers 255 patients from a 5-year retrospective review at a specialized clinic.
• Skin prick test results are available for multiple perioperative agent categories, enabling detailed sensitization analysis.
• The study identifies specific causative agents for 38 patients with a history of reactions, providing diagnostic clarity.

Limitations

• The dataset is small in scale (22.7 KB), derived from a single clinic, limiting generalizability.
• Data is presented in a DOCX report format, not a structured tabular dataset, complicating direct computational analysis.
• The retrospective design may introduce selection bias, as patients were referred for evaluation of reactions or preoperative concerns.

Provenance

Source

Retrospective review at a tertiary allergy clinic in Lebanon.

Collection Method

Medical record review and standardized skin prick testing for perioperative agents.

Time Range

2018 to 2023.

Freshness

Data covers the period 2018-2023, with the record last updated in March 2026.

Geography

Lebanon.