Immune Cell and Protein Signatures in Acute Gouty Arthritis

A dataset from a multi-omics study investigating immune remodeling in acute gouty arthritis. It includes results from Mendelian randomization, mass cytometry, single-cell RNA-seq re-analysis, and plasma proteomics across multiple patient cohorts. The data was published by Peng Zhang on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Validate genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results.
• Analyze peripheral CD4+ naïve T cell expansion and functional remodeling during acute gout flares using mass cytometry data.
• Investigate inflammatory transcriptional features in CD4+ naïve T cells, such as S100A8/S100A9 upregulation, from single-cell RNA-seq data.
• Assess the exploratory potential of plasma proteins like MMP1 and S100A12 for stratifying 12-week recurrence risk in acute gout patients.

Strengths

• Integrates multiple analysis methods: bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq, and plasma proteomics.
• Includes data from distinct patient cohorts: GA-A (n=25), GA-R (n=22), healthy controls (n=9), and independent training (n=40) and validation (n=64) cohorts.
• Identifies specific candidate biomarkers and pathways, such as MMP1, S100A12, and MIF–CXCR2/ANXA1–FPR1 signaling interactions.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (13.3 KB), indicating it likely contains summary results rather than raw experimental data.

Provenance

Source

Peng Zhang via figshare.

Collection Method

Bidirectional Mendelian randomization, mass cytometry (CyTOF) of PBMCs, re-analysis of public single-cell RNA-seq data, and plasma proteomic quantification via Olink platform.

Freshness

Last updated 2026-05-26 06:03:53; freshness should be verified.

Geography

Genetic data from European ancestry GWAS; patient cohorts are described as Chinese.