Table 1: Th1 Bias in ABCD1-Deficient Mouse CD4+ T Cells

A 16.4 KB dataset published on figshare by Reina Maeda on May 20, 2026. It contains data from a study investigating the immunometabolic link between peroxisomal lipid metabolism and T cell polarization in a mouse model of X-linked adrenoleukodystrophy. The findings define a 25-HC–LXR–Blimp-1 signaling axis regulating CD4+ T-cell differentiation.

Use Cases

• Analyze Th1/Th2 cytokine profiles (IFN-γ, IL-10) based on immunological assays described.
• Investigate gene expression patterns (Ifng, Tbx21, Prdm1, Abca1, Srebf1, Ch25h) based on transcriptional profiling mentioned.
• Model the effects of pharmacological LXR modulation (SR9238, T0901317, 25-HC) on T cell polarization based on the described mechanistic validation.

Strengths

• Data is associated with a specific, peer-reviewed research finding published on figshare.
• The dataset is openly available under a CC-BY-4.0 license.
• The description provides a detailed mechanistic pathway (25-HC–LXR–Blimp-1) for the observed phenotype.

Limitations

• The dataset is very small at 16.4 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from in vivo and in vitro immunological and transcriptomic assays on Abcd1-deficient mice.

Freshness

Last updated 2026-05-20 05:50:17; freshness should be verified.