Table 1_Pharmacological and genetic modulation of IL-32 expression in intestinal epithelia

3.9 MB of experimental data from a study investigating IL-32's role in HIV-1 latency. The dataset, authored by Etiene Moreira Gabriel and last updated on 2026-05-26, contains results from assays measuring IL-32 expression and HIV-1 outgrowth in co-cultures of intestinal epithelial cells and CD4+ T-cells from ART-treated individuals.

Use Cases

• Analyze the effects of cytokine treatments (IL-22, ATRA, RGZ) on IL-32 isoform expression based on RT-PCR/ELISA data mentioned in the description.
• Compare HIV-1 outgrowth in co-cultures using control versus IL32-knockout intestinal epithelial cells based on the viral outgrowth assay results.
• Investigate transcriptional profile differences between control and IL32KO cells exposed to TNF based on whole-genome RNA-Sequencing data referenced.
• Correlate soluble and intracellular HIV-p24 levels with different experimental conditions based on ELISA and flow cytometry measurements described.

Strengths

• Data is associated with a detailed, peer-reviewed-style methodology section describing cell lines, treatments, and assays.
• The dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• File size is 3.9 MB, indicating a focused and likely manageable dataset for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain statistical analyses.
• The data reflects a specific, controlled laboratory study, which may limit generalizability to in vivo contexts.

Provenance

Source

figshare, author Etiene Moreira Gabriel.

Collection Method

Experimental data from cell culture assays, CRISPR/Cas9 gene editing, RT-PCR, ELISA, RNA-Sequencing, and viral outgrowth assays.

Freshness

Last updated 2026-05-26 07:48:57; freshness should be verified.