Table 1_Pharmacological sedation strategies for therapeutic gastrointestinal endoscopy: a

A systematic review and network meta-analysis of 60 randomised controlled trials involving 7,071 patients, published on figshare in 2026. The study compares 32 pharmacological sedation regimens for therapeutic gastrointestinal endoscopy, analyzing outcomes like procedural interference, hypoxia, hypotension, and recovery time. The analysis was conducted by Hui Jiang using data from PubMed, Embase, and Cochrane CENTRAL.

Use Cases

• Compare the efficacy of different drug combinations like ketamine-propofol and propofol-opioid based on reported outcome measures.
• Assess the safety profiles of sedation regimens based on metrics for hypoxia, hypotension, and bradycardia.
• Inform clinical decision-making for individualized sedation strategy selection based on patient and procedural needs described in the review.
• Validate or update clinical guidelines for therapeutic gastrointestinal endoscopy using the synthesized evidence from 60 trials.

Strengths

• Analysis is based on 60 randomised controlled trials, a substantial evidence base.
• Includes data from 7,071 patients, providing a significant sample size for meta-analysis.
• Compares 32 distinct pharmacological regimens, offering a broad comparison.
• Employs established methodological frameworks including Cochrane RoB 2.0 and GRADE for assessing evidence quality.

Limitations

• The primary data file is a 19.1 MB DOCX document; the underlying structured trial data is not directly available in a machine-readable format.
• Row count and column-level documentation for any underlying data tables are unknown.
• Freshness should be verified as the last update is listed as 2026-04-21, which is a future date.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of randomised controlled trials from PubMed, Embase, and Cochrane CENTRAL.

Freshness

Last updated 2026-04-21 04:23:04