Systematic Review of Pharmacometric Models for Opioid Disposition in Pregnancy

Ten studies modeling opioid disposition in pregnant individuals were identified in a systematic review covering literature from database inception to September 2025. The review, authored by Syed Saoud Zaidi and published on figshare in April 2026, critically appraises published population pharmacokinetic and physiologically based pharmacokinetic models. It synthesizes data on model structure, parameterization, and evaluation strategies.

Use Cases

• Benchmarking new opioid pharmacokinetic models against existing structural and methodological features identified in the review.
• Identifying gaps in model development, such as limited verification datasets or incomplete gestational physiology, for future research planning.
• Informing standardized documentation practices for pharmacometric models based on reported reproducibility concerns.
• Supporting model-informed perinatal opioid therapy by reviewing linkages between pharmacokinetics and clinical outcomes.

Strengths

• Systematic review methodology with a structured PubMed search covering literature up to September 2025.
• Analysis of 10 included studies, with specific findings on fentanyl having the most studies and pregnancy as a significant covariate.
• Published under a CC-BY-4.0 license, facilitating open sharing and reuse.

Limitations

• The dataset is a 65.8 KB DOCX document, which is a small text file and not a structured data table.
• Column-level documentation is absent; the content is a narrative review and field semantics must be inferred from the text.
• The review's findings are constrained by the limited number of primary studies and sparse empirical data available in the field.

Provenance

Source

figshare

Collection Method

Structured PubMed search and systematic review.

Time Range

Database inception to September 2025.

Freshness

Last updated 2026-04-20 05:19:26.

Geography

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