Salvia Miltiorrhiza Polysaccharide Characteristics and Anti-Cancer Activity

96.52% total polysaccharide content was measured for the novel acidic polysaccharide SMP-3 extracted from Salvia miltiorrhiza roots. The dataset contains physicochemical characterization data and in vitro anti-colorectal cancer activity results for SMP-3, both alone and combined with the drug regorafenib. Xinran Wang published this research data on figshare in April 2026.

Use Cases

• Analyze the relationship between polysaccharide composition (e.g., galacturonic acid, glucuronic acid molar ratios) and observed cytotoxic activity against HCT116 cells.
• Model the combined effect of SMP-3 and regorafenib (REG) on cell cycle arrest (G0/G1) and apoptosis markers (p21, Bax, caspase-3).
• Correlate structural features (α- and β-glycosidic linkages, amorphous structure) with biological mechanisms like STAT3, AKT, and ERK pathway suppression.
• Compare dose- and time-dependent cytotoxicity data for HCT116 cancer cells versus minimal toxicity data for normal FHC cells.

Strengths

• Provides detailed monosaccharide composition with molar ratios for 6 components.
• Reports specific molecular weight (61.3 kDa) and total polysaccharide content (96.52%).
• Includes biological assay results for single and combination drug treatments.

Limitations

• Dataset is very small (16.6 KB), likely containing summary results rather than raw experimental data.
• In vitro cell line results (HCT116, FHC) may not directly translate to in vivo or clinical outcomes.
• Unknown row count and specific column structure limits direct computational analysis.

Provenance

Source

Research data from Xinran Wang, published on figshare.

Collection Method

Polysaccharide extracted via hot water, purified by column chromatography, characterized with FT-IR, NMR, XRD, CD spectroscopy, and tested with in vitro cell assays.

Time Range

null

Freshness

Last updated April 2026.

Geography

null