Placental Transcriptome Profiles for Congenital Chagas Disease Transmission

RNA-seq data from placental tissues of newborns with congenital Chagas disease, exposed but uninfected, and unexposed controls. The dataset includes differential gene expression and co-expression network analysis results, identifying genes like CEMIP, PRRX1, and CGB5. It was uploaded by Sofia Apodaca on March 18, 2026.

Use Cases

• Identify gene expression signatures associated with vertical transmission based on comparisons between infected, exposed, and control placental samples.
• Analyze pathways related to extracellular matrix remodeling and cell adhesion based on findings for genes like CEMIP, CADM3, and CDH11.
• Investigate the role of long non-coding RNAs in congenital infection based on the analysis of ENSG00000304767 and MIR4300HG.
• Perform cell type enrichment analysis based on the reported overrepresentation of extravillous trophoblasts and syncytiotrophoblasts in different sample groups.

Strengths

• Data is derived from a transcriptomic (RNA-seq) analysis, which provides a high-resolution molecular profile.
• Analysis includes multiple comparisons between three distinct clinical groups (M+B+, M+B−, M−B−).
• Findings are supported by multiple analytical methods, including differential expression, gene set enrichment, and co-expression network analysis.

Limitations

• The dataset is small, at 91.9 KB, suggesting it contains summary results rather than raw sequencing data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analyses.

Provenance

Source

figshare, uploaded by Sofia Apodaca.

Collection Method

Transcriptomic analysis (RNA-seq) of placental tissues from deliveries with different Chagas disease infection statuses.

Freshness

Last updated 2026-03-18 06:43:08