Plasma Proteome Mendelian Randomization Results for Gastric Cancer Drug Targets

A 2026 study by Peng Zhi identifies 13 ancestry-specific plasma protein targets for gastric cancer using Mendelian randomization. The dataset includes results for four significant targets in European populations and nine in East Asian populations, derived from proteomic and genetic analyses. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identifying ancestry-specific drug targets for gastric cancer based on Mendelian randomization results.
• Prioritizing proteins for experimental validation based on reported associations with gastric cancer susceptibility.
• Exploring cross-ancestry therapeutic potential using the identified repurposable drug, digoxin.

Strengths

• Identifies 13 specific protein targets, including five novel candidates, for gastric cancer.
• Provides ancestry-stratified results for European and East Asian populations.
• Includes experimental validation for two key targets (NME4 and ICAM5) in cell lines and tissue.

Limitations

• The dataset is very small (11.8 KB), suggesting it contains summary results rather than raw or large-scale data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

Peng Zhi via figshare.

Collection Method

Mendelian randomization and colocalization analyses of plasma proteome data, followed by single-cell RNA sequencing, molecular docking, and experimental validation.

Freshness

Last updated 2026-05-01 04:19:28.

Geography

Analyses cover European and East Asian populations.