Platelet Morphology and Activation Profiles from Early Alzheimer's Patients

Platelets from early-stage Alzheimer's patients show enhanced amyloid binding and an elevated open canalicular system. The dataset likely contains measurements from patients and age-matched controls, including platelet surface APP/Aβ immunoreactivity, dense granule counts, and integrin activation levels. Author Lili Donner published the data on figshare under a CC-BY-4.0 license.

Use Cases

• Identify potential blood-based biomarkers for early Alzheimer's prognosis based on platelet surface APP/Aβ binding.
• Analyze sex-specific differences in disease pathology based on integrin αIIbβ3 activation profiles.
• Study platelet morphology changes in neurodegenerative disease based on open canalicular system area and dense granule counts.
• Compare platelet activation states between patient groups and controls based on flow cytometry and electron microscopy data.

Strengths

• Data is focused on a specific clinical question: platelet parameters in early Alzheimer's disease.
• Includes sex-specific analysis, a dimension mentioned as important in the conclusion.
• Published under an open CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (13.8 KB), indicating a limited scope.

Provenance

Source

figshare

Collection Method

Patients diagnosed with early Alzheimer's disease were analyzed for extracellular Aβ binding to platelets, platelet morphology, and platelet activation, and were compared with age-matched controls.

Freshness

Last updated 2026-03-19 05:19:22; freshness should be verified.