Platycodin D Effects on Cardiac Hypertrophy and Apoptosis in a Mouse Model

A 10.3 KB Excel file contains data from a study investigating Platycodin D's therapeutic effects on heart failure. Yingrui Li authored this dataset, which was last updated on 2026-05-26. The research employed a mouse model and network pharmacology to explore inhibition of the p53-dependent BCL-2/Bax/caspase-3 signaling pathway.

Use Cases

• Analyze dose-response relationships of Platycodin D based on the described administration of 12.5, 25, or 50 mg/kg/d for 4 weeks.
• Investigate molecular mechanisms of cardioprotection based on the described p53, Bcl-2, Bax, and caspase-3 signaling pathway.
• Compare therapeutic effects with a p53 inhibitor based on the described use of pifithrin-α (PFT-α).
• Model cardiomyocyte apoptosis pathways based on the described role of apoptosis in cardiac hypertrophy progression.

Strengths

• Data is associated with a specific, peer-reviewed research methodology described in the summary.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 10.3 KB, indicating limited scope.

Provenance

Source

figshare, author Yingrui Li

Collection Method

Experimental data from a mouse model of isoprenaline (ISO)-induced heart failure, combined with network pharmacology and molecular docking analysis.

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.