PM2.5 and House Dust Mite Effects on Allergic Rhinitis in Mouse Model

2026 research data from a study investigating how PM2.5 exacerbates house dust mite-induced allergic rhinitis via the STING/NF-κB pathway. The dataset contains experimental results from in vivo mouse models and in vitro human nasal epithelial cells, assessing rhinitis symptoms, Th2 inflammation, and epithelial barrier integrity. It is a 6.3 KB Excel file with results from bioinformatics analysis and functional validation using the STING inhibitor H-151.

Use Cases

• Analyze correlations between PM2.5/HDM co-exposure levels and measured Th2 inflammation markers like IL-4, IL-5, IL-13, and IgE.
• Model the relationship between STING/NF-κB pathway activation and the downregulation of epithelial barrier proteins E-cadherin and Claudin-1.
• Compare nasal symptom severity scores across different experimental groups (PM2.5 alone, HDM alone, and co-exposure).
• Validate bioinformatics findings linking PM2.5 exposure to TNF/NF-κB signaling using the in vivo and in vitro experimental data.

Strengths

• Data is directly tied to a 2026 peer-reviewed research study with a clear experimental methodology.
• Combines multiple data types: bioinformatics analysis, in vivo mouse model results, and in vitro human cell experiments.
• Includes results from functional validation using a specific STING inhibitor (H-151).
• Published under a permissive CC BY 4.0 license for clear reuse.

Limitations

• Very small data scale at 6.3 KB, indicating it contains summary results, not raw high-throughput data.
• Unknown row and column counts prevent assessment of dataset granularity or feature count.
• Experimental data is from controlled laboratory models (BALB/c mice, HNEpCs), which may not fully translate to human populations.

Provenance

Source

figshare, authored by Youwei Bao.

Collection Method

Generated from combined bioinformatics analysis, in vivo mouse experiments, and in vitro human cell culture studies.

Time Range

Data pertains to the 2026 study period.

Freshness

Last updated March 24, 2026.

Geography

Laboratory study; geographic origin of samples or models is not specified.