Table 1_Polygenic risk score and phenome-wide association study of the Epstein-Barr virus
by Bahram Namjou·Updated 3mo ago
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Description
UK Biobank and Milieu Intérieur cohorts, totaling 10,695 individuals, plus GWAS summary statistics for 4,365 individuals of African ancestry, were used to develop a multi-ancestry polygenic risk score for EBV antibody response. The dataset, authored by Bahram Namjou and last updated in March 2026, contains results from genetic association studies and PheWAS analyses linking the PRS to autoimmune diseases like multiple sclerosis and Celiac disease.
Use Cases
Validate polygenic risk score models for EBV antibody response based on the described multi-ancestry Bayesian approach (PRS-CSx).
Investigate genetic associations with autoimmune diseases based on the PheWAS results for multiple sclerosis and Celiac disease.
Replicate GWAS findings for SNPs in the MHC region and loci near ARMC3 and NRG3 genes.
Assess the predictive performance of genetic profiling for serologic traits in cohorts lacking direct measurements.
Strengths
Data integrates multiple cohorts, including the UK Biobank (N=9,695) and the Milieu Intérieur cohort (N=1,000).
Includes GWAS summary statistics for individuals of African ancestry (N=4,365), supporting multi-ancestry analysis.
The PRS model achieved a validation performance with AUC ranging from 65% to 72%.