Table 1_Porphyromonas gingivalis outer membrane vesicles prevent the induction of toleroge

A 142.1 KB document authored by Brenda Lara and last updated in May 2026. This research investigates how outer membrane vesicles from the periodontal pathogen Porphyromonas gingivalis disrupt the immune tolerance mechanisms at the maternal-fetal interface. The findings demonstrate that these vesicles reprogram trophoblast cells, preventing the induction of tolerogenic dendritic cells.

Use Cases

• Analyze the mechanistic link between periodontal infection and adverse pregnancy outcomes based on the described in vitro experimental model.
• Study the reprogramming of trophoblast secretory activity based on the measured changes in cytokine and chemokine expression.
• Investigate the disruption of tolerogenic dendritic cell differentiation based on the described phenotypic markers like CD86 and interleukin-10.
• Model the impact of bacterial virulence factors on immune homeostasis based on the described effects of outer membrane vesicles.

Strengths

• The dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• The description provides a detailed account of the experimental methods and biological findings.

Limitations

• The dataset is a 142.1 KB DOCX file, indicating a very limited scope, likely containing a single table or summary.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

In vitro experiments using a first-trimester trophoblast cell line exposed to bacterial outer membrane vesicles.

Time Range

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Freshness

Last updated 2026-05-08 05:54:52; freshness should be verified.

Geography

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