CoV2-BMEPu: Preclinical Vaccine Evaluation Data for SARS-CoV-2 Protection

Preclinical evaluation data for a multi-epitope mRNA vaccine candidate, CoV2-BMEPu, designed for broad SARS-CoV-2 protection. The dataset includes results from in vitro expression, innate immune activation, and immunogenicity and protective efficacy studies in mouse models. Authored by Laura Marcos-Villar and published on figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Benchmark vaccine immunogenicity based on antibody and T-cell response data described.
• Analyze cross-variant neutralization breadth using results against ancestral and Omicron subvariants.
• Model multi-epitope vaccine design strategies using the conserved regions from Spike, Membrane, and Nucleocapsid proteins mentioned.
• Evaluate mRNA vaccine platform efficacy based on in vitro expression and in vivo protection results.

Strengths

• Dataset includes results from multiple preclinical assays, including in vitro expression, antibody neutralization, and T-cell responses.
• Protective efficacy is demonstrated with complete protection against lethal challenge in a transgenic mouse model.
• The vaccine candidate targets conserved regions from multiple SARS-CoV-2 proteins (S, M, N) and RBD segments.

Limitations

• Dataset size is very small at 31.6 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data likely generated from laboratory experiments described in the associated research document.

Freshness

Last updated 2026-05-05 05:29:17; freshness should be verified.