Tdacp Vaccine: Reproductive Safety and Immunogenicity Study in Sprague-Dawley Rats

Han Chu's study evaluates the reproductive safety and immunogenicity of an adsorbed acellular diphtheria-tetanus-pertussis (reduced-dose) combined vaccine (Tdacp) in Sprague-Dawley rats. The dataset, last updated on 2026-05-26, includes results from a preclinical trial with 160 rats across four groups. It provides experimental evidence on gamete maturation, mating performance, fertility, embryo-fetal development, and antibody responses.

Use Cases

• Assessing reproductive toxicity of vaccines based on parameters like sperm quality and estrous cycle.
• Evaluating vaccine immunogenicity based on antibody response data against diphtheria, tetanus, and pertussis antigens.
• Comparing embryo-fetal developmental outcomes between vaccine-treated and control groups.
• Analyzing the relationship between vaccine dose and clinical signs, food consumption, and body weight in animal models.

Strengths

• Study design includes 160 Sprague-Dawley rats across four groups (negative control, adjuvant control, low-dose, high-dose).
• Evaluates multiple endpoints including clinical signs, reproductive organ coefficients, sperm parameters, and fetal development.
• License is CC-BY-4.0, allowing for broad reuse.

Limitations

• Dataset is a 89.3 KB DOCX file; the underlying tabular data is not directly accessible.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Data is from a single preclinical animal study, limiting generalizability to human populations.

Provenance

Source

Author Han Chu, published on figshare.

Collection Method

Preclinical study involving repeated intramuscular administration of a vaccine to Sprague-Dawley rats.

Freshness

Last updated 2026-05-26 05:26:06.

Geography

Study likely conducted in a laboratory setting; specific location is unknown.