Case Report of Probable Metformin-Associated Erythema Multiforme

A single clinical case report describes a 51-year-old man developing erythema multiforme after starting metformin therapy. The report, authored by Long Luo and published on figshare under a CC-BY-4.0 license, provides a detailed patient history and a practical reference for causality assessment in polypharmacy. It was last updated on 2026-05-14.

Use Cases

• Training or testing causality assessment algorithms based on the detailed clinical timeline and drug rechallenge information.
• Supporting literature reviews on rare cutaneous adverse reactions to metformin.
• Educating medical students and residents on differential diagnosis of drug-induced skin eruptions.
• Informing clinical guidelines for managing suspected drug reactions in patients with polypharmacy.

Strengths

• Provides a detailed, peer-reviewed case report with a specific patient history, including age (51), drug dosages (500 mg twice daily), and timeline (onset at 10 days).
• Includes a documented causality assessment of 'probable' for metformin and describes a successful drug rechallenge protocol for aspirin and atorvastatin.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Dataset is a single case report (20.8 KB DOCX file), representing an extremely limited sample size of one patient.
• Row count and column-level documentation are absent; the data is unstructured narrative text.
• Freshness should be verified; the last update date is in the future (2026-05-14), which may indicate a placeholder or error.

Provenance

Source

Long Luo via figshare

Collection Method

Clinical case documentation and literature review.

Freshness

Last updated 2026-05-14 14:22:02