Probiotic Heavy Metal Detoxification Assessment in Simulated Gut Models

Marco Pane's dataset, published on figshare in April 2026, contains results from a study evaluating three probiotic lactobacilli strains for detoxifying cadmium, chromium, mercury, and lead. The data likely includes measurements from a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model and a gut ex vivo system, assessing strain survival, metal sequestration, and effects on intestinal barrier integrity.

Use Cases

• Compare strain-specific detoxification efficacy based on the described performance of Lactiplantibacillus plantarum LP14, Lactobacillus crispatus LCR04, and Lactobacillus acidophilus LA12.
• Analyze the relationship between probiotic metabolic activity and heavy metal removal based on the mechanistic finding linking proliferation to substantial HM removal.
• Model the mitigation of heavy metal-induced intestinal damage based on the described restoration of permeability and cytokine profiles in the ex vivo system.

Strengths

• Data is derived from a dynamic Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model, simulating sequential gastric, small-intestinal, and colonic conditions.
• Results include assessments of three specific probiotic strains (LP14, LCR04, LA12) against four specific heavy metals (cadmium, chromium, mercury, lead).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (16.3 KB), indicating limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Experimental assessment using SHIME® model and gut ex vivo system.

Freshness

Last updated 2026-04-29 05:56:56; freshness should be verified.