Probiotic Potential of L. plantarum LBK from Koumiss in Hyperuricemic Mice

73 lactic acid bacteria were isolated from Koumiss and assessed for properties like inosine degradation and xanthine oxidase inhibition. The dataset includes results from in vitro experiments and subsequent in vivo studies on mice, where a high dose of L. plantarum LBK significantly reduced serum uric acid, urea nitrogen, and creatinine levels. The data, authored by Panpan Zhao and last updated in May 2026, also covers 16S rRNA sequencing and non-targeted metabolomic analysis of gut microbiota and metabolic pathways.

Use Cases

• Identify probiotic candidates based on in vitro assays for xanthine oxidase inhibition and acid tolerance.
• Analyze the therapeutic effects of L. plantarum LBK on serum biomarkers (uric acid, urea nitrogen, creatinine) in a mouse model.
• Study the modulation of gut microbiota composition, such as the Firmicutes/Bacteroidetes ratio, following probiotic treatment.
• Investigate changes in metabolic pathways like cysteine and methionine or vitamin B6 metabolism via non-targeted metabolomic data.
• Examine gene expression changes in kidney transporters (ABCG2, URAT1, GLUT9) related to uric acid excretion.

Strengths

• Includes data from a multi-stage study covering in vitro screening of 73 isolates and in vivo validation in a mouse model.
• Integrates multiple analysis types: biochemical assays, 16S rRNA sequencing, and non-targeted metabolomics.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is very small (36.5 KB), suggesting limited scope or summary-level data rather than raw experimental records.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare, author Panpan Zhao.

Collection Method

Data likely derived from laboratory experiments isolating bacteria from Koumiss and testing in mice.

Freshness

Last updated 2026-05-20 05:38:20; freshness should be verified.