SARS-CoV-2 Immune Response Profiles in Young Adult Vaccine Trial

Andrew Fiore-Gartland's dataset profiles SARS-CoV-2 virus shedding, antibody neutralization, and T-cell receptor repertoires from 209 participants in the CoVPN 3006 COVID-19 vaccine trial. It contains measurements from pre-exposure, post-vaccination, and post-breakthrough blood samples.

Use Cases

• Analyze correlations between antibody neutralization levels and T-cell receptor repertoire breadth across vaccination and infection exposures.
• Model virus shedding duration and peak nasal viral load as outcomes of hybrid immunological exposures.
• Compare immune response profiles, including TCR expansions, between primary infections and post-vaccination breakthrough cases.

Strengths

• Data originates from a defined clinical trial cohort of 209 participants.
• Includes paired measurements of humoral (antibody) and cellular (TCR) immunity from the same blood samples.
• Protocol enables TCR profiling from remnant coagulated blood material, a resource-efficient method.

Limitations

• The dataset is small in file size (412.9 KB), indicating limited scope and likely aggregated summary statistics rather than raw individual-level data.
• Sample size of 209 young adults may limit generalizability to other age groups or populations.
• Specific column names and row counts are not provided, obscuring the dataset's granular structure.

Provenance

Source

Andrew Fiore-Gartland via figshare.

Collection Method

Data collected from a subset of participants in the CoVPN 3006 COVID-19 vaccine trial, with TCR sequencing and antibody measurements performed on blood samples.

Time Range

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Freshness

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Geography

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