Prognostic Impact of p53 and HER2 in 290 Colorectal Carcinoma Cases

Michal Grus published a dataset on 2026-05-14 containing immunohistochemistry results for p53 and HER2 from 290 surgically resected colorectal cancer cases. The data includes survival analysis results over 10 years and correlations with clinicopathological features. It was created for a retrospective study evaluating the prognostic significance of these biomarkers.

Use Cases

• Survival analysis based on p53 expression patterns (wild-type, overexpression, null) and HER2 status.
• Correlating biomarker profiles with tumor location and molecular pathways like chromosomal instability.
• Investigating associations between HER2 expression and extraintestinal immunophenotypic profiles.
• Training predictive models for 5-year relative risk of death using p53 status and patient age.

Strengths

• Contains data from 290 patient cases, providing a substantive sample size for analysis.
• Includes 10-year overall survival data with Kaplan-Meier and Cox regression analyses.
• Immunohistochemistry results are categorized using established clinical criteria (CAP criteria for HER2).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Michal Grus

Collection Method

Retrospective analysis of tissue microarrays from archival formalin-fixed paraffin-embedded samples.

Freshness

Last updated 2026-05-14 05:01:28; freshness should be verified.