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Eight studies involving 911 patients with advanced non-small cell lung cancer (NSCLC) were included in this systematic review and meta-analysis. The work, authored by Jia-jia Lin and last updated in May 2026, found emotional distress was significantly associated with reduced overall survival and progression-free survival. The certainty of evidence was judged as low for overall survival and objective response rate, and very low for progression-free survival.
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