Prognostic Nutritional Index and Breast Cancer Outcomes: A Meta-Analysis of 9 Studies

A systematic review and meta-analysis of 9 studies comprising 3,718 breast cancer patients receiving neoadjuvant chemotherapy, evaluating the prognostic value of the pre-treatment Prognostic Nutritional Index (PNI). The analysis, authored by Meihui Shan and last updated in April 2026, synthesized hazard ratios and odds ratios for overall survival, disease-free survival, and pathological complete response. The dataset is a summary document of the meta-analysis results.

Use Cases

• Assessing the association between pre-treatment PNI and overall survival in breast cancer patients based on the reported hazard ratio.
• Evaluating the relationship between PNI and pathological complete response rates based on the reported odds ratio.
• Investigating potential effect modifiers like sample size or geographic region based on the subgroup analyses mentioned.
• Validating the prognostic utility of a simple clinical marker for risk stratification as discussed in the conclusions.

Strengths

• Analysis is based on 9 studies with a pooled sample of 3,718 patients.
• Reports specific effect estimates with 95% confidence intervals (e.g., HR=0.36 for OS).
• Includes robustness checks via sensitivity and subgroup analyses as described.
• Has a registered systematic review protocol (CRD420251268856).

Limitations

• The primary data file is a 12.0 KB DOCX document; the underlying tabular data (e.g., study-level results) is not directly provided in a structured format.
• Row count for any potential summary tables is unknown, which may limit suitability assessment.
• Column-level documentation for any included tables is absent; field semantics must be inferred from the document.

Provenance

Source

figshare, authored by Meihui Shan.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library up to November 2025.

Time Range

Literature search conducted through November 2025; publication date of the meta-analysis is not specified.

Freshness

Last updated 2026-04-27 04:14:45; freshness should be verified.

Geography

Geographic coverage of the included studies is not specified, though subgroup analysis indicated region as a potential modifier.