Meta-Analysis of Salidroside Effects on Rodent NAFLD Models

A 2025 meta-analysis synthesizes results from 12 eligible animal studies published up to June 2025. The dataset, compiled by Shuai Li, contains statistical results evaluating the therapeutic effect of salidroside on rodent models of non-alcoholic fatty liver disease (NAFLD). It includes standardized mean difference (SMD) values for numerous outcome indicators related to liver health, metabolism, and inflammation.

Use Cases

• Analyze dose-response relationships by comparing SMD values for hepatic TG and serum TC across different salidroside dosage groups (e.g., ≥100 mg/kg/d).
• Compare treatment efficacy across species by examining differences in NAS score and serum TG improvement SMDs between rat and mouse models.
• Investigate the impact of treatment duration on liver function by modeling the relationship between SMD values for serum ALT/AST and treatment periods (e.g., ≤4 weeks).
• Explore correlations between oxidative stress markers (MDA, GSH, SOD SMDs) and inflammatory cytokines (IL-6, IL-1β, MCP-1 SMDs) to understand the compound's mechanism.
• Assess publication bias and result robustness using the provided sensitivity analysis and funnel plot data referenced in the study.

Strengths

• Aggregates data from 12 independent animal studies identified through a systematic search of eight major databases.
• Reports quantitative results for over 20 distinct outcome indicators, each with a calculated Standardized Mean Difference (SMD).
• Employs the SYRCLE bias risk assessment tool for quality evaluation of included literature.

Limitations

• The dataset is derived from a meta-analysis of only 12 animal studies, representing a limited sample of the available preclinical research.
• Findings are specific to rodent models, and the authors note significant differences from human pathology, limiting direct clinical translation.
• The authors report a certain degree of publication bias was present in the included studies.

Provenance

Source

figshare, authored by Shuai Li.

Collection Method

Systematic review and meta-analysis of animal studies from eight databases (Web of Science, PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, CBM).

Time Range

Literature search covered studies published up to June 2025.

Freshness

Includes studies published up to June 2025; the meta-analysis itself was posted in April 2026.