Proteome-Wide Mendelian Randomization Results for Schizophrenia Biomarker Discovery
by Jingyu Lin·Updated 3mo ago
402.3 KB1files
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Description
A 2026 analysis by Jingyu Lin presents results from proteome-wide Mendelian randomization and colocalization studies to identify plasma proteins with causal links to schizophrenia. The primary analysis used genetic instruments for 4,907 plasma proteins from 35,559 Icelanders and summary statistics for schizophrenia from 35,476 cases and 46,839 controls. Findings were validated using external datasets from the Fenland study, UK Biobank Pharma Proteomics Project, and GTEx brain expression data.
Use Cases
Prioritizing candidate plasma protein biomarkers for schizophrenia based on reported odds ratios and p-values.
Validating genetic associations using external cis-pQTL and brain eQTL data sources mentioned in the description.
Investigating protein-protein interaction networks with known antipsychotic drug targets.
Assessing shared causal variants via Bayesian colocalization posterior probabilities (PPH4).
Strengths
Primary analysis includes genetic data for 4,907 plasma proteins from a cohort of 35,559 individuals.
Schizophrenia outcome data is based on a large-scale consortium (PGC) with 35,476 cases and 46,839 controls.
Results were externally validated across three independent datasets (Fenland, UKB-PPP, GTEx).
Specific odds ratios and p-values are reported for seven significant protein associations.
Limitations
Column-level documentation is absent; field semantics must be inferred after download.
Row count is unknown, which may limit suitability assessment.
The 402.3 KB file size suggests a limited scope, likely containing summary results rather than raw genetic data.
Provenance
Source
figshare, author Jingyu Lin.
Collection Method
Proteome-wide Mendelian randomization and colocalization analyses using genetic association data.
Time Range
Publication date suggests analysis circa 2026.
Freshness
Last updated 2026-03-18 07:41:54.
Geography
Primary genetic data from Icelandic cohort; validation data includes UK (Fenland, UK Biobank) and GTEx tissues.