Table 1_Proton pump inhibitor exposure modulates functional and transcriptional responses

Romen Singh Naorem published a computational and experimental study on May 8, 2026, investigating the effects of proton pump inhibitors (PPIs) on the probiotic bacterium Lactobacillus acidophilus. The research integrates subtractive genomics, molecular docking, dynamics simulations, antimicrobial assays, and transcriptional analysis. The dataset, shared under a CC-BY-4.0 license on figshare, consists of a 1004.6 KB DOCX file containing the study's findings.

Use Cases

• Modeling protein-drug interactions based on molecular docking results for targets like MurA, MurB, and AtpD.
• Analyzing transcriptional responses to drug exposure based on qRT-PCR data for genes involved in cell-wall production and energy generation.
• Simulating protein-ligand complex stability based on molecular dynamics simulation results described in the study.
• Investigating dose-dependent growth inhibition of probiotic bacteria based on the described antimicrobial assay results.

Strengths

• The study employs an integrated multi-method framework, including in-silico and in-vitro techniques.
• Specific molecular targets and pathways, such as ATP synthesis and peptidoglycan biosynthesis, are identified and analyzed.
• The dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a single 1004.6 KB DOCX document; raw experimental or simulation data files are not provided.
• The findings reflect species-specific responses under in vitro conditions, as noted by the author, limiting generalizability.
• Column-level documentation is absent; data structure and semantics must be inferred from the document text.

Provenance

Source

figshare, authored by Romen Singh Naorem.

Collection Method

Integrated computational and experimental study using subtractive genomics, molecular docking, MD simulations, antimicrobial assays, and qRT-PCR.

Time Range

The study was published in 2026; specific experimental dates are not provided.

Freshness

Last updated 2026-05-08 05:55:49.

Geography

Geographic scope of the research is not specified.