Pubertal Dysfunctions in Pediatric Intracranial Germ Cell Tumors, 60 Patients

60 pediatric patients with intracranial germ cell tumors were followed between 1996 and 2023 at the Royal Marsden Hospital, UK. The dataset includes clinical, radiological, histopathological, and hormonal data, focusing on the prevalence and types of pubertal disorders. It was authored by Cristina Partenope and last updated in May 2026.

Use Cases

• Analyzing the association between tumor location (suprasellar, pineal, bifocal) and specific pubertal dysfunction types based on the description.
• Studying the prevalence and resolution of pseudo-precocious puberty (PPP) following tumor treatment based on the clinical outcomes described.
• Investigating the incidence and management of hypogonadotrophic hypogonadism (HH) in adolescent survivors based on the reported hormonal data.
• Comparing treatment modalities (surgery, chemotherapy, radiotherapy) and their correlation with endocrine sequelae based on the described cohort.

Strengths

• Median follow-up of 22.9 months provides longitudinal clinical data.
• Detailed classification of pubertal dysfunctions (PPP, CPP, HH) with specific patient counts (e.g., 27 patients with disorders).
• Clear breakdown of tumor types (70% germinomas) and locations (59% suprasellar).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 52.8 KB, indicating limited scope.

Provenance

Source

Royal Marsden Hospital, UK

Collection Method

Clinical data collection from a patient cohort.

Time Range

1996 to 2023

Freshness

Last updated 2026-05-19 05:28:35; freshness should be verified.

Geography

United Kingdom