Pyoverdine Effects on Endothelial Barrier Dysfunction Under Hyperglycemia

Guixiang Zhang published this dataset on figshare in 2026. It contains experimental data from a study investigating how the bacterial siderophore pyoverdine impairs vascular endothelial barrier function, particularly under high glucose conditions. The data likely includes results from RNA-seq transcriptomics, cell viability assays, and measurements of reactive oxygen species and barrier integrity using HUVEC cells.

Use Cases

• Analyze gene expression changes related to iron homeostasis and extracellular matrix based on the RNA-seq results mentioned in the description.
• Model the relationship between pyoverdine exposure, oxidative stress, and cell viability based on the in vitro assay data.
• Investigate the combined effect of high glucose and pyoverdine on tight junction protein expression (e.g., ZO-1, Claudin-5) based on the functional assessments described.

Strengths

• Data is associated with a detailed scientific study described in the summary, providing context.
• The dataset is licensed under CC-BY-4.0, allowing for open reuse with attribution.
• File size is 69.8 KB, indicating a focused and likely manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (69.8 KB), indicating limited scope and scale.

Provenance

Source

Guixiang Zhang via figshare

Collection Method

Experimental data from in vitro studies using Human Umbilical Vein Endothelial Cells (HUVECs), including RNA-seq, cell assays, and microscopy.

Freshness

Last updated 2026-04-17 04:12:03; freshness should be verified.