QDPR rs3733570 Association with Type 2 Diabetes and Diabetic Kidney Disease in Chinese Han

1,844 participants from Kai Luan General Hospital were genotyped for the QDPR rs3733570 polymorphism. The study found the AA genotype was associated with increased risk of type 2 diabetes and, in carriers with dyslipidemia, diabetic kidney disease. Author Minda Dong published this data on figshare under a CC-BY-4.0 license in 2026.

Use Cases

• Validate genetic associations for type 2 diabetes based on the QDPR rs3733570 polymorphism.
• Investigate gene-lipid interaction effects on diabetic kidney disease risk using stratified analysis results.
• Perform meta-analysis on genetic risk factors for diabetic complications by combining with other cohort data.
• Train predictive models for diabetic kidney disease susceptibility incorporating genetic and lipid profile features.

Strengths

• Includes data from 1,844 participants, split into 690 healthy controls, 818 T2DM patients, and 336 DKD patients.
• Provides specific odds ratios and confidence intervals for genetic associations (e.g., OR=1.33 for T2DM risk).
• Focuses on a specific ethnic population (Chinese Han), which can reduce confounding genetic heterogeneity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single hospital cohort in Tangshan, China.

Provenance

Source

Kai Luan General Hospital, Tangshan, China.

Collection Method

Genetic analysis using PCR-RFLP genotyping on participant samples.

Freshness

Last updated 2026-05-12 04:19:13; freshness should be verified.

Geography

Chinese Han population from Tangshan, China.