Table 1_Qualitative evaluation of pharmacological strategy for connective tissue diseases

105 CTD-GBS patient cases were systematically reviewed from PubMed, Embase, and Web of Science to evaluate treatment efficacy. The analysis, conducted by Gaodi Yuan and last updated in March 2026, used a Generalized Linear Mixed Model to assess associations between treatment regimens and neurological improvement. Results suggest intensive combination therapy may offer advantages over intravenous immunoglobulin monotherapy.

Use Cases

• Compare treatment efficacy based on the described regimens like IVIG monotherapy versus glucocorticoids combined with immunosuppressants.
• Model predictors of neurological recovery based on covariates such as mechanical ventilation status.
• Analyze clinical trends within specific patient subgroups, such as the systemic lupus erythematosus (SLE) cohort.
• Inform hypothesis generation for future prospective studies on rare disease combinations.

Strengths

• Analysis is based on 105 identified patient cases, providing a quantitative basis for a rare condition.
• Multivariable GLMM analysis adjusted for key covariates like mechanical ventilation and publication year.
• Clear reporting of statistical results, including adjusted odds ratios and confidence intervals.

Limitations

• Data is derived from retrospective case reports and series, which the authors note limits causal inference.
• The dataset is a 178.8 KB DOCX file; the underlying structured data (rows, columns) is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the review text.

Provenance

Source

Gaodi Yuan, published on figshare.

Collection Method

Systematic review of case reports and series retrieved from PubMed, Embase, and Web of Science.

Freshness

Last updated 2026-03-18 06:57:29