Quercetin Effects on Skin Inflammation and Fibrosis in Systemic Sclerosis

Xiangzhen Kong published a research article on figshare on 2026-06-03 detailing the effects of quercetin on systemic sclerosis. The 3.2 MB DOCX file contains results from in vitro studies with patient-derived CD4+ T cells and an in vivo bleomycin-induced mouse model. The study identifies the RELA/c-Jun axis as a target for modulating T cell pathogenicity.

Use Cases

• Identify molecular targets for autoimmune disease therapy based on the described RELA/c-Jun axis.
• Study the modulation of Th17 cell responses based on the described suppression of IL-17A and IFN-γ secretion.
• Validate drug-target interactions based on the described DARTS and CETSA assay methodologies.
• Assess pre-clinical efficacy of natural compounds based on the described attenuation of skin thickness and collagen deposition in a mouse model.

Strengths

• The dataset is a 3.2 MB research document with a specific mechanistic focus on the RELA/c-Jun axis.
• Data is derived from both primary human cells (SSc patient CD4+ T cells) and an animal model (bleomycin-induced SSc mice).
• The license is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained within a DOCX file, which may require parsing to extract structured information.

Provenance

Source

Xiangzhen Kong via figshare

Collection Method

Research study utilizing primary cell isolation, animal models, and molecular assays (DARTS, CETSA).

Freshness

Last updated 2026-06-03 05:16:39; freshness should be verified.