Raspberry Extract Effects on MAFLD in Mice via Gut Microbiota and Purine Metabolism

Yanyan Gao's research article, uploaded to figshare on 2026-04-30, details a preclinical study investigating raspberry aqueous extract's effects on metabolism-associated fatty liver disease (MAFLD) in mice. The 29.6 KB document describes integrated multi-omics analyses, including 16S rRNA sequencing, serum/hepatic biochemical detection, and in vitro experiments. The study identifies a regulatory axis involving the gut bacterium Ileibacterium and the metabolite inosine.

Use Cases

• Study the effects of raspberry extract on hepatic steatosis based on histopathological examination results described.
• Analyze gut microbiota remodeling in a MAFLD mouse model based on 16S rRNA microbial sequencing data mentioned.
• Investigate the correlation between Ileibacterium abundance and hepatic inosine content based on Spearman correlation analysis results.
• Examine the in vitro effects of inosine on lipotoxicity in AML12 hepatocytes based on described cellular experiments.

Strengths

• The study employs integrated multi-omics analyses, including 16S rRNA sequencing and metabolomics, as described.
• Specific experimental details are provided, such as a 12-week high-fat diet for model establishment and RE doses of 1 g/kg/d and 2 g/kg/d.
• The research identifies a specific gut bacterium (Ileibacterium) and metabolite (inosine) as core mediators, providing a mechanistic hypothesis.

Limitations

• The primary data file is a 29.6 KB DOCX document, suggesting the dataset is likely a research article summary rather than raw experimental data.
• Row count and column-level documentation for any underlying data are unknown, limiting suitability assessment.
• The description is detailed but does not confirm the availability of structured, machine-readable data tables for direct analysis.

Provenance

Source

Yanyan Gao via figshare.

Collection Method

Preclinical animal study using C57BL/6 mice fed a high-fat diet, with subsequent multi-omics analyses.

Freshness

Last updated 2026-04-30 04:16:23; freshness should be verified.