Pediatric ARDS Ventilation Outcomes from a 7-Day Landmark Cohort

January 2012 to June 2024 data from a retrospective case-control study of 106 pediatric patients with moderate-to-severe ARDS in two Chinese PICUs. The dataset compares clinical outcomes between high-frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV) groups after genetic matching. It includes primary and secondary outcome measures such as 28-day mortality, ventilator-free days, and survival rates stratified by pre-intubation P/F ratios.

Use Cases

• Compare 28-day mortality rates between HFOV and CMV groups for pediatric ARDS patients.
• Analyze ventilator-free days (VFD) and PICU-free days (IFD) outcomes across matched patient cohorts.
• Model survival time and rates stratified by pre-intubation PaO2/FiO2 (P/F) ratio categories.
• Assess the association of ventilation type with mortality using adjusted odds ratios from logistic regression.

Strengths

• Includes 106 matched patient records (53 per group) from a 12.5-year study period (Jan 2012-Jun 2024).
• Data is balanced using a genetic matching approach, with sensitivity and robustness analyses confirming stability.
• Contains multiple clinical outcome measures: 28-day mortality, VFD, IFD, survival time, and stratified survival rates.

Limitations

• Small sample size of 106 total patients limits statistical power and generalizability of findings.
• Single-center study from two PICUs in China, introducing potential geographic and institutional bias.
• Retrospective observational design cannot establish causality, only associations.

Provenance

Source

Feifan Jin, Chongqing Medical University.

Collection Method

Retrospective case-control study using genetic matching in R software on patient records.

Time Range

January 2012 to June 2024.

Freshness

Data covers up to June 2024, with the record last updated in March 2026.

Geography

Two pediatric intensive care units (PICUs) of Chongqing Medical University, China.