Plasma Cytokine Reference Intervals for Healthy Adults in Eastern China

Eastern China's Jiangsu Province provided the reference population for this dataset. It contains reference intervals for plasma levels of IFN-α, TNF-α, IL-12p70, and IFN-γ, measured via flow cytometry from 728 healthy adults between July and November 2025. The study was authored by Qian Liu and published on figshare under a CC-BY-4.0 license.

Use Cases

• Establishing laboratory reference ranges for cytokine assays based on the reported percentile intervals.
• Assessing patient immune status by comparing individual cytokine levels against the healthy population benchmarks.
• Supporting clinical decision-making for immune-related diseases using the provided flow cytometry-based reference values.
• Designing studies on immune modulation and inflammatory processes with baseline cytokine levels from a specific geographic cohort.

Strengths

• Reference intervals are derived from a cohort of 728 healthy adults, providing a substantial sample size.
• The study follows established CLSI C28-A3 and WS/T 402-2024 guidelines for deriving reference intervals.
• Specific reference intervals are provided for four key cytokines: IFN-α (0.13–5.81 pg/mL), TNF-α (0.60–4.89 pg/mL), IL-12p70 (0.24–5.44 pg/mL), and IFN-γ (0.50–6.88 pg/mL).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single-center study in eastern China, which may limit generalizability to other populations.

Provenance

Source

figshare

Collection Method

Plasma cytokine levels were measured via flow cytometry from healthy adult volunteers.

Time Range

Data collection occurred between July and November 2025.

Freshness

Last updated 2026-05-14 04:22:03; freshness should be verified.

Geography

Healthy adults from the Jiangsu region in eastern China.