Refractive Outcomes After ROP Treatments: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis of 86 studies covering 10,269 eyes, published on figshare in May 2026. It compares long-term refractive outcomes following anti-VEGF, laser photocoagulation, cryotherapy, and vitrectomy treatments for retinopathy of prematurity. The analysis includes pooled estimates for mean spherical equivalent and high myopia prevalence.

Use Cases

• Compare treatment efficacy for refractive outcomes based on pooled data from 86 studies.
• Assess the risk of high myopia development following different ROP interventions.
• Inform clinical decision-making by analyzing outcomes by treatment zone (Zone I vs. Zone II/III).
• Evaluate the heterogeneity of results across studies included in the meta-analysis.

Strengths

• Analysis is based on a substantial evidence base of 86 studies and 10,269 eyes.
• Provides pooled quantitative estimates for key outcomes like mean spherical equivalent and high myopia prevalence.
• Includes prespecified subgroup analyses comparing treatment zone and monotherapy vs. combination therapy.

Limitations

• Dataset is a 52.4 KB DOCX document; the underlying tabular data from the meta-analysis is not provided as a separate structured file.
• Column-level documentation for the meta-analysis data is absent; field semantics must be inferred from the manuscript.
• The data reflects findings aggregated from literature up to July 2025; individual study data points are not accessible.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis performed using PubMed, Embase, Web of Science, and the Cochrane Library.

Time Range

Literature search from database inception to July 2025.

Freshness

Last updated 2026-05-15 06:20:46.