Immune Cell and Metabolite Associations with Intrahepatic Cholangiocarcinoma

Mendelian randomization analysis identifies three specific immune cell traits and two blood metabolites as causal risk factors for intrahepatic cholangiocarcinoma. The dataset includes odds ratios and confidence intervals from a two-sample MR study, with experimental validation targeting the DLAT-leucine metabolic axis. Author Zhipeng Ye published the data under a CC-BY-4.0 license in May 2026.

Use Cases

• Validate causal links between immune phenotypes and cancer risk based on Mendelian randomization results
• Investigate the mediating role of N-acetylleucine and fructosyllysine in cancer development
• Design in vitro experiments targeting metabolic pathways like DLAT-leucine based on identified associations

Strengths

• Includes specific odds ratios and p-values for three immune cell traits (e.g., activated CD4 regulatory T cells OR=1.0005)
• Dataset is 1.8 MB, indicating a focused and likely manageable size for analysis
• Results are supported by sensitivity analyses and in vitro experimental validation mentioned in the description

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment for large-scale modeling
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Two-sample Mendelian randomization study with mediation analysis and in vitro experimental validation.

Freshness

Last updated 2026-05-22 06:10:28